| ARNI |
Sacubitril-valsartan |
50-100 mg BID (dose rounded) |
200 mg BID (dose rounded) |
| ACE inhibitor |
Enalapril |
1.25-2.5 mg BID |
10 mg BID / 20 mg BID in NYHA IV |
| |
Lisinopril |
2.5-5 mg daily |
20-35 mg daily |
| |
Perindopril |
2-4 mg daily |
4-8 mg daily |
| |
Ramipril |
1.25-2.5 mg BID |
5 mg BID |
| |
Trandalopril |
1-2 mg daily |
4 mg daily |
| ARB |
Candesartan |
4-8 mg daily |
32 mg daily |
| |
Valsartan |
40 mg BID |
160 mg BID |
| Beta-blocker |
Carvedilol |
3.125 mg BID |
25 mg BID / 50 mg BID (>85 kg) |
| |
Bisoprolol |
1.25 mg daily |
10 mg daily |
| |
Metoprolol (CR/XL) |
12.5-25 mg daily |
200 mg daily |
| MRA |
Spironolactone |
12.5 mg daily |
25-50 mg daily |
| |
Eplerenone |
25 mg daily |
50 mg daily |
| SGLT2 inhibitor |
Dapagliflozin |
10 mg daily |
10 mg daily |
| |
Empagliflozin |
10 mg daily |
10-25 mg daily |
| |
Canagliflozin |
100 mg daily |
100-300 mg daily |
| Sinus node inhibitor |
Ivabradine |
2.5-5 mg BID |
7.5 mg BID |
| sGC stimulator |
Vericiguat |
2.5 mg daily |
10 mg daily |
| Vasodilator |
Hydralazine/Isosorbide Dinitrate |
10-37.5 mg TID / 10-20 mg TID |
75-100 mg TID or QID / 40 mg TID |
| Cardiac glycosides |
Digoxin |
0.0625-0.125 mg daily |
N/A: monitor for toxicity |
